HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VAIRABLE DOMAIN VL AND A DERIVATIVE VHH

What are proposed are: monoclonal antibodies of the type IgG comprising variable domains in the form of a combination of a derivative VHH with a variable domain of a light chain VL. The antibodies mentioned may comprise amino acid substitutions in positions 44 and/or 45 (according to the Kabat numbe...

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Main Authors EKIMOVA, VICTORIA MIKHAILOVNA, ULITIN, ANDREY BORISOVICH, EVDOKIMOV, STANISLAV RUDOLFOVICH, GONCHAROVA, OLGA VLADIMIROVNA, NEMANKIN, TIMOFEY ALEKSANDROVICH, CHERNYH, YULIA SERGEEVNA, IVANOV, ROMAN ALEXEEVICH, MOROZOV, DMITRIY VALENTINOVICH, SOFRONOVA, EKATERINA VLADIMIROVNA, KORZHAVIN, DMITRIY VALERIEVICH, USTYUGOV, YAKOV YUREVICH, SOLOVIEV, VALERIY VLADIMIROVICH, CHERNOVSKAYA, TATYANA VENIAMINOVNA
Format Patent
LanguageEnglish
Published 15.08.2016
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:What are proposed are: monoclonal antibodies of the type IgG comprising variable domains in the form of a combination of a derivative VHH with a variable domain of a light chain VL. The antibodies mentioned may comprise amino acid substitutions in positions 44 and/or 45 (according to the Kabat numbering scheme) or combinations thereof. The antibodies described have increased affinity and improved aggregation stability.
Bibliography:Application Number: PH20161501391