BRUTON`S TYROSINE KINASE INHIBITORS

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in comb...

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Main Authors WAN, ZHAO-KUI, SPRINGER, JOHN ROBERT, SAIAH, EDDINE, ZAPF, CHRISTOPH WOLFGANG, GRAPPERHAUS, MARGARET LANAHAN, SCHNUTE, MARK EDWARD, XING, LI, SCHMIDT, MICHELLE, ANN, WALKER, DANIEL PATRICK, HAN, SEUNGIL, DEVADAS, BALEKUDRU, HUGHES, ROBERT OWEN, GARLAND, DANNY JAMES, HOCKERMAN, SUSAN LANDIS, SELNESS, SHAUN RAJ
Format Patent
LanguageEnglish
Published 29.06.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)
Bibliography:Application Number: PH20151500940