2-AMINO, 6-PHENYL SUBSTITUTED PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS

The present invention provides the compound l-(3,3-Dimethylbutyl) -3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea or a pharmaceutically acceptable salt thereof, that inhibits Raf and, therefore, may be useful in treating cancer.

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Bibliographic Details
Main Authors FLYNN, DANIEL L, WOLFANGEL, CRAIG D, KAUFMAN, MICHAEL D, ALLGEIER, MATTHEW CARL, PATEL, PHENIL J
Format Patent
LanguageEnglish
Published 24.11.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides the compound l-(3,3-Dimethylbutyl) -3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea or a pharmaceutically acceptable salt thereof, that inhibits Raf and, therefore, may be useful in treating cancer.
Bibliography:Application Number: PH20141501986