INMUNOCITOQUINA PARA ACTIVAR EL RECEPTOR IL-10RA HUMANO Y SU USO

• Main Authors: KONONOV, Aleksey Vladimirovich, IAKOVLEV, Pavel Andreevich, EVDOKIMOV, Stanislav Rudolfovich, TSYMPILOV, Vladimir Sergeevich, MOROZOV, Dmitry Valentinovich, EVDOKIMOVSKAIA, Iuliia Viktorovna, SOLOVYEV, Valery Vladimirovich, AGEEV, Sergei Andreevich, SMIRNOVA, Iana Andreevna, KOLOSOVA, Elena Sergeevna
• Format: Patent
• Language: Spanish
• Published: 13.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Referido a una inmunocitoquina aislada para activar el receptor IL-10R[alfa] humano, que comprende un complejo homodimerico basado en IL-10 y fragmento Fc de IgG1 humana, en el que el monomero basado en IL-10 y fragmento Fc de IgG1 humana comprende la secuencia de aminoacidos de SEQ ID NO:1; un acido nucleico aislado que codifica la inmunocitoquina; un vector de expresion que comprende el acido nucleico; un metodo para producir una celula huesped para producir la inmunocitoquina; una composicion farmaceutica que comprenden dicha inmunocitoquina y su uso para tratar una enfermedad oncologica, tales como HNSCC (carcinoma de celulas escamosas de cabeza y cuello), cancer de cuello uterino, entre otros. The present invention relates to the field of biotechnology and medicine, in particular to an immunocytokine for activating the human IL-10Rα receptor. The invention further relates to nucleic acids encoding said immunocytokine, expression vectors, host cells and methods for producing same, methods for producing the immunocytokine, pharmaceutical compositions comprising the above immunocytokine, pharmaceutical compositions comprising the above immunocytokine and other therapeutically active compounds, methods for treating an oncological disease and the uses of the immunocytokine or pharmaceutical compositions thereof for treating an oncological disease.