ADMINISTRACION ORAL DE OLIGONUCLEOTIDOS

• Main Authors: NOBLE, Stewart Alwyl, SHEAR, Charles Lester, OERUM, Henrik
• Format: Patent
• Language: Spanish
• Published: 04.04.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

La presente invencion se refiere a composiciones, metodos para fabricarlas y formas farmaceuticas, de los oligonucleotidos que comprenden (i) un oligonucleotido de la presente descripcion, por ejemplo, un aptamero de ASO, ARNsi, ARNsh, ADN o ARN, vector de terapia genica, ARNmi, imitador de ARNmi, antimiR, senuelo de ADN o ARN, oligonucleotido CpG, o cualquier oligonucleotido terapeutico o de diagnostico conocido en la tecnica, y (ii) un derivado del acido caprilico, por ejemplo, 5-CNAC. En algunos aspectos, la composicion de oligonucleotidos se formula para su administracion al tracto gastrointestinal. Por lo tanto, en algunos aspectos, la presente descripcion proporciona composiciones de oligonucleotidos para administracion oral que comprenden un oligonucleotido terapeutico o de diagnostico (por ejemplo, un ASO) y un derivado del acido caprilico (por ejemplo, 5-CNAC o su derivado). The present disclosure provides oligonucleotide compositions comprising (1) an oligonucleotide of the present disclosure, e.g., an ASO, siRNA, shRNA, DNA or RNA aptamer, gene therapy vector, miRNA, miRNA mimic, antimiR, DNA or RNA decoy, CpG oligonucleotide, or any therapeutic or diagnostic oligonucleotide known in the art, and (ii) a caprylic acid derivative, e.g., 5-CNAC. In some aspects, the oligonucleotide composition is formulated for delivery to the gastrointestinal tract. Thus, some aspects, the present disclosure provides oligonucleotide compositions for oral delivery comprising a therapeutic or diagnostic oligonucleotide (e.g., an ASO) and a caprylic acid derivative (e.g., 5-CNAC or de derivative thereof).