2-[(4S)-8-FLUORO-2-[4-(3-METOXIFENIL)PIPERAZIN-1-IL]-3-[2-METOXI-5-(TRIFLUOROMETIL)FENIL]-4H-QUINAZOLIN-4-IL] ACETATO DE SODIO Y COMPOSICIONES FARMACEUTICAS DEL MISMO

• Main Authors: BUSCHMANN, Helmut, REDMER, Jessica, HAWE, Andrea, GOLDNER, Thomas, ROSA, Monica, LUCKE, Matthias, HOHMANN, Dorothea
• Format: Patent
• Language: Spanish
• Published: 24.03.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE REFIERE A UNA COMPOSICION FARMACEUTICA LIQUIDA QUE COMPRENDE UNA SAL DE SODIO DE LETERMOVIR QUE COMPRENDE AL MENOS UN EXCIPIENTE SELECCIONADO DEL GRUPO QUE CONSISTE EN UN CARBOHIDRATO TAL COMO SACAROSA Y MANITOL, UN AMINOACIDO TAL COMO FENILALANINA, UN COMPUESTO POLIALCOXI TAL COMO UN POLOXAMERO 188 Y UNA POLIVINILPIRROLIDONA (PVP), EN PARTICULAR PVP PF12; EN DONDE LA COMPOSICION TIENE UN PH EN EL INTERVALO DE 7 A 8. TAMBIEN SE REFIERE A UN METODO DE PREPARACION DE LA COMPOSICION. DICHA COMPOSICION DE LA SAL DE SODIO DE LETERMOVIR ES UTIL EN EL TRATAMIENTO DE INFECCIONES POR CITOMEGALOVIRUS HUMANO (HCMV). The present invention relates to new stable pharmaceutical compositions containing sodium 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)-phenyl]-4H-quinazolin-4-yl]acetate that are essentially free of complexing solubilizing agents, such as PEG, cyclodextrin, lysin, arginine, in particular HPBCD. The invention further relates to methods of preparation of said pharmaceutical compositions. The invention further relates to use of said pharmaceutical compositions in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.