COMPOSICIONES DE VACUNA ESTABLES QUE COMPRENDEN INTER ALIA UN FLAVIVIRUS RECOMBINANTE VIVO ATENUADO Y PROCESO PARA LA PREPARACION DE LAS MISMAS

• Main Authors: BARASKAR, Sandeep Dinkar, GHODEKAR, Shashikant Janardan, DHERE, Rajeev Mhalasakant, KUMAR, Vinit, MEHLA, Rajeev, YEOLEKAR, Leena Ravindra, SONAR, Rohit Bapurav
• Format: Patent
• Language: Spanish
• Published: 19.01.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Composiciones inmunogenicas liofilizadas estables que comprenden, entre otros, flavivirus vivos atenuados recombinantes, mas preferiblemente virus del dengue recombinantes vivos atenuados, al menos un hidrato de carbono, al menos un aminoacido, y que son particularmente susceptibles de tratamientos de liofilizacion rapida en donde, la composicion conserva las caracteristicas deseadas de un virus, que incluye la viabilidad, inmunogenicidad y estabilidad del virus. La mencionada composicion inmunogenica esta libre de conservantes, polimeros y surfactantes. Los metodos para fabricar las mencionadas composiciones inmunogenicas liofilizadas estables Stable lyophilized immunogenic compositions include inter alia live attenuated recombinant flaviviruses, more preferably live attenuated recombinant dengue viruses, at least one carbohydrate, at least one amino acid and is particularly amenable to rapid freeze-drying treatments wherein, the composition preserves desired characteristics of a virus, including virus viability, immunogenicity and stability. The immunogenic composition is devoid of preservatives, polymers and surfactants. The methods for manufacturing the stable lyophilized immunogenic compositions are also provided.