COMPUESTOS DE IMIDAZO[4,5-C]QUINOLIN-2-ONA Y SU USO EN EL TRATAMIENTO DEL CANCER

• Main Authors: HUNT, Thomas Anthony, PIKE, Kurt Gordon, BARLAAM, Bernard Christophe, EATHERTON, Andrew John
• Format: Patent
• Language: Spanish
• Published: 22.08.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Referido a compuestos imidazo[4,5-c]quinolin-2-ona de formula (I), donde R1 es metilo; R2 es hidro o metilo; X es 1 o 2; R3 es cicloalquilo C4-C6 opcionalmente sustituido con un grupo metoxi, isopropilo, entre otros; R4 es hidro o metilo; y R5 es hidro o fluor. Tambien se refiere a composiciones farmaceuticas que los comprenden y metodos de preparacion. Dichos compuestos modulan selectivamente la cinasa de la ataxia telangiectasia mutada (ATM), por lo que son utiles para tratar o prevenir una enfermedad mediada por ATM, incluido el cancer. The specification generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where x, R1, R2, R3, R4 and R5 have any of the meanings defined herein. The specification also relates to the use of compounds of Formula (I) and salts thereof to treat or prevent ATM mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising substituted imidazo[4,5-c]quinolin-2-one compounds and pharmaceutically acceptable salts thereof; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; and intermediates useful in such manufacture.