2-(MORFOLIN-4-IL)-1,7-NAFTIRIDINAS

• Main Authors: KOPPITZ, Marcus, EBERSPACHER, Uwe, WORTMANN, Lars, SIEMEISTER, Gerhard, WEDLER, Christine, BADER, Benjamin, MOOSMAYER, Dieter, VON NUSSBAUM, Franz, LUCKING, Ulrich, WENGNER, Antje Margret, BONE, Wilhelm, LIENAU, Philip, SCHICK, Hans, LEFRANC, Julien, BRIEM, Hans, EIS, Knut, GRUDZINSKA-GOEBEL, Joanna
• Format: Patent
• Language: Spanish
• Published: 15.06.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Se refiere a un compuesto de formula I, donde: R1 es 1H-pirrol-2-il, 1H-pirrol-3-il o 1H-pirazol-3-il; R2 es hidrogeno, halogeno, CN, entre otros; R3 y R4 son independientemente hidrogeno o metilo, adicionalmente se refiere a una compuesto Ib, donde: R1 es 1H-pirazol-3-il, R2 es hidrogeno, halogeno, entre otros; R4 es hidrogeno o metilo. Son compuestos preferidos: 4-[(2-(morfolin-4-il)-8-[2H-pirazol-3-il]-[1,7]-naftiridin-4-il]fenil-N-etoxicarbonil-S-metilsulfoximida; 4-[(2-(morfolin-4-il)-8-[2H-pirazol-3-il]-[1,7]-naftiridin-4-il]fenil-S-metilsulfoximida; entre otros. Tambien se refiere a una composicion y a una combinacion farmaceutica. Dichos compuestos derivados de 2-(morfolin-4-il)-1,7-naftiridina son utiles en el tratamiento de enfermedades hiperproliferativas The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.