INDAZOLES

• Main Authors: JONES, PETER, SABNIS, YOGESH ANIL, WAKENHUT, FLORIAN MICHEL, COE, JOTHAM WADSWORTH, KORTUM, STEVEN WADE, DEHNHARDT, CHRISTOPH MARTIN, WHITLOCK, GAVIN ALISTAIR
• Format: Patent
• Language: Spanish
• Published: 30.08.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE REFIERE A COMPUESTOS DERIVADOS DE INDAZOLES DE FORMULA (I) DONDE R1 ES HALO; R2 ES ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON FLUOR; X ES UN ENLACE, -CO-, -SO2- O -CH2-; R3 ES ARIL1, HET1, ENTRE OTROS, DONDE ARIL1 ES FENILO O NAFTILO; HET1 ES UN HETEROCICLO AROMATICO DE 5 O 6 MIEMBROS; n ES 1 O 2. SON COMPUESTOS PREFERIDOS: {2-[6-(2-ETIL-5-FLUORO-4-HIDROXI-FENIL)-1H-INDAZOL-3-IL]-1,4,6,7-TETRAHIDRO-IMIDAZO[4,5-c]PIRIDIN-5-IL}-(4-FLUORO-FENIL)-METANONA; {2-[6-(2-ETIL-5-FLUORO-4-HIDROXI-FENIL)-1H-INDAZOL-3-IL]-1,4,6,7-TETRAHIDRO-IMIDAZO[4,5-c]PIRIDIN-5-IL}-ISOTIAZOL-3-IL-METANONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE JANUS QUINASA (JAK) SIENDO UTILES EN EL TRATAMIENTO DE ASMA, RINITIS ALERGICA, BRONQUITIS CRONICA A method of treating a disease or condition for which a JAK inhibitor is indicated in a subject in need of such treatment, comprising administering to the subject a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, and particularly, a method for the treatment of various inflammatory diseases, particularly psoriasis, asthma and COPD.