COMPUESTOS Y COMPOSICIONES COMO INHIBIDORES DE LA QUINASA c-KIT

• Main Authors: LOREN, JON, NGUYEN, BAO, LI, XIAOLIN, LIU, XIAODONG, PETRASSI, HANK MICHAEL JAMES, NABAKKA, JULIET, YEH, VINCE, MOLTENI, VALENTINA
• Format: Patent
• Language: Spanish
• Published: 20.07.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA DE FORMULA (I) O (II) DONDE m ES 1 O 4; R20 ES H, HALO, ALQUILO(C1-C6), HALOALCOXILO(C1-C6), ENTRE OTROS; R1 ES HALO O ALQUILO(C1-C6); R11 ES H, HALO O ALQUILO(C1-C6); R2 ES R3 O L2R3, EN DONDE R3 ES HETEROCICLOALQUILO DE 4 A 6 MIEMBROS, ENTRE OTROS; L2 ES NH, ENTRE OTROS; L1 ES UN ENLACE, NH O C(O)NH. SON COMPUESTOS PREFERIDOS: N-{5-[3-(AZETIDIN-1-IL)-1,2,4-OXADIAZOL-5-IL]-2-METILFENIL}IMIDAZO[1,2-a]PIRIDINA-3-CARBOXAMIDA; N-{5-[3-(3,3-DIFLUOROAZETIDIN-1-IL)-1,2,4-OXADIAZOL-5-IL]-2-METILFENIL}IMIDAZO[1,2-a]PIRIDINA-3-CARBOXAMIDA; N-{5-[3-(4,4-DIFLUOROPIPERIDIN-1-IL)-1,2,4-OXADIAZOL-5-IL]-2-METILFENIL}IMIDAZO[1,2-a]PIRIDINA-3-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LAS QUINASAS PDGFR O c-KIT SIENDO UTILES EN EL TRATAMIENTO DE ASMA, RINITIS ALERGICA, FIBROSIS PULMONAR The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFR ) kinases.