VACUNAS DE VIRUS VARICELA ZOSTER INACTIVADO, METODOS DE PRODUCCION Y USO DE LAS MISMAS

• Main Authors: BARR, COLLEEN M, YAGODICH, MARY, KRAH, DAVID L, DEHAVEN, JILL, KRISS, JENNIFER A
• Format: Patent
• Language: Spanish
• Published: 21.11.2013
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

SE REFIERE A COMPOSICIONES FARMACEUTICAS QUE COMPRENDE UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE VIRUS VARICELA ZOSTER INACTIVO (VVZ) CUYA INFECTIVIDAD ES MENOR A 0,002 UNIDADES FORMADORAS DE PLACAS (UFP)/ml., DONDE LA CEPA VVZ ES UNA CEPA OKA, LIOFILIZADA E INACTIVADA POR IRRADIACION GAMMA DE 5- 50 kGy CON RAYOS 60Co. DICHA COMPOSICION ES UTIL EN EL TRATAMINETO DEL HERPES ZOSTER The invention provides an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of the VZV is undetectable and wherein the inactivated VZV induces an immune response against VZV when administered to a patient. In embodiments of the compositions described herein, the VZV is inactivated with gamma radiation. The invention also provides a method of preparing an inactivated VZV vaccine, the method comprising gamma irradiating a sample comprising a VZV using from about 5 kGy to about 50 kGy of gamma radiation. Also provided by the invention herein is a method of treatment of or immunization against HZ or other disease associated with the reactivation of VZV, the method comprising administering to a subject a vaccine or pharmaceutical composition comprising a therapeutically effective amount of an inactivated VZV and a pharmaceutically acceptable carrier, wherein the VZV is inactivated by gamma irradiation.