INHIBIDORES DE OXADIAZOL DE LA PRODUCCION DE LEUCOTRIENO

• Main Authors: WU, LIFEN, BOSANAC, TODD, OLAGUE, ALAN, TYE, HEATHER, HUBER, JOHN D, BARTOLOZZI, ALESSANDRA, CHEN, ZHIDONG, DE LOMBAERT, STEPHANE, LIU, WEIMIN, MORWICK, TINA MARIE, RIETHER, DORIS, LO, HO-YIN, LOKE, PIU LENG, ZINDELL, RENEE M
• Format: Patent
• Language: Spanish
• Published: 21.06.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE REFIERE A COMPUESTOS DERIVADOS DE OXADIAZOL DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H, ALQUILO(C1-C7) O CARBOCICLO(C3-C10); R3 ES HETEROARILO DE 5 A 11 MIEMBROS OPCIONALMENTE SUSTITUIDO CON ALCOXI(C1-C5), HALOGENO, -O-BENCILO, ENTRE OTROS; R4 ES H, ALQUILO(C1-C3), HALOGENO O NITRILO; R5 ES ALQUILO(C1-C6), CARBOCICLO(C3-C10), HETEROCICLO DE 3 A 11 MIEMBROS, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(3-{2-[4-(5-METOXIPIRIDIN-3-IL)FENIL]-3-METILBUTAN-2-IL}-1,2,4-OXADIAZOL-5-IL)PIRAZINA; 5-{4-[3-METIL-2-(5-FENIL-1,2,4-OXADIAZOL-3-IL)BUTAN-2-IL]FENIL}PIRIMIDIN-2-AMINA; 5-(4-{3-METIL-2-[5-(PIRIDIN-3-IL)-1,2,4-OXADIAZOL-3-IL]BUTAN-2-IL}FENIL)PIRIMIDIN-2-AMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA ACTIVADORA DE LA 5-LIPOXIGENASA (FLAP) SIENDO UTILES EN EL TRATAMIENTO DE ASMA, ALERGIA, ARTRITIS REUMATOIDE, ESCLEROSIS MULTIPLE, ATEROSCLEROSIS The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.