[1,2,4]TRIAZOLO[1,5-A]PIRIDINAS COMO INHIBIDORES DE CINASA

• Main Authors: AUCLAIR, ERIC, MIDDLEMISS, DAVID, ROUX, JACQUES LE, LERICHE, CAROLINE
• Format: Patent
• Language: Spanish
• Published: 20.02.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE REFIERE A COMPUESTOS DERIVADOS DE [1,2,4]TRIAZOLO[1,5-a]PIRIDINAS DE FORMULA (I) DONDE A1 Y A2 SON CADA UNO N O C; R1 Y R2 SON CADA UNO H, ALQUILO(C1-C4), ARILO, HALOGENO, ENTRE OTROS; R3 ES H, ALQUILO(C1-C4), CICLOALQUILO, ARILO, CN, ENTRE OTROS; X ES UN ENLACE O (CH2)aW(CH2)b, (CH2)aW(CH2)bY(CH2)c, ENTRE OTROS, EN DONDE a, b Y c SON CADA UNO DE 0 A 3; W E Y SON CADA UNO -CO-, -O-, -SO2-, -CH2-, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE 4-CLORO-3-{2-[4-(2-PIRROLIDIN-1-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; CLORHIDRATO DE 4-CLORO-3-{8-METIL-2-[4-(2-PIRROLIDIN-1-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; 4-CLORO-3-{2-[4-(2-MORFOLIN-4-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA SIENDO UTILES EN EL TRATAMIENTO DE INFARTO DE MIOCARDIO, CANCER, ARTRITIS, RETINOPATIA, GLAUCOMA The invention is directed to certain novel compounds, methods for producing them and methods for treating or ameliorating a kinase-mediated disorder. More particularly, this invention is directed to substituted triazolopyridine compounds useful as selective kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase-mediated disorder. In particular, the methods relate to treating or ameliorating a kinase-mediated disorder including cardiovascular diseases, diabetes, diabetes-associated disorders, inflammatory diseases, immunological disorders, cancer and diseases of the eye such as retinopathies or macular degeneration or other vitreoretinal diseases, and the like.