HIDRATOS DE DIFENILAZETIDINONA CRISTALINOS Y COMPOSICIONES QUE COMPRENDEN A ESTOS COMPUESTOS

• Main Authors: DUFFY REGINA, WOLLMANN THEODOR ANDREAS, CULLMANN FRANK
• Format: Patent
• Language: Spanish
• Published: 31.08.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

REFERIDA A UN HIDRATO DE DIFENILAZETIDINONA CRISTALINO DE FORMULA (I), DONDE n TIENE UN VALOR DE 0,5 A 1,8. DICHO HIDRATO CRISTALINO TIENE UN PICO PRINCIPAL DE 20,83 GRADOS 2 TETA ± 0,2 GRADOS 2 TETA EN EL XRPD MEDIDO CON RADIACION CuKALFA. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE DISOLVER EL COMPUESTO AMORFO DE FORMULA (II) EN UN DISOLVENTE ORGANICO TAL COMO ETANOL O UNA MEZCLA DE ETANOL/AGUA, Y ANADIR ESTA SOLUCION A UNA SUSPENSION DE CRISTALES DE SIEMBRA DEL COMPUESTO DE FORMULA (I) Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylamide ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl)-amide (A) in hydrate form (I), is new. Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylamide ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl)-amide (A) in hydrate form of formula (I), is new. n : 0.5-1.8, preferably 1-1.2. Independent claims are included for: (1) a medicament comprising (I); and (2) the preparation of (I). [Image] ACTIVITY : Antilipemic. MECHANISM OF ACTION : None given.