FORMAS CRISTALINAS DE GLYT1

• Main Authors: DEYNET-VUCENOVIC ANNETTE, GRASSMANN OLAF, PINARD EMMANUEL, SCHWITTER URS, LINDENSTRUTH KAI, BUDENDORF ANDRE, DIODONE RALPH, ROHRER FRANZISKA E
• Format: Patent
• Language: Spanish
• Published: 28.11.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

SE REFIERE A UNA FORMA CRSITALINA A DE LA [4-(3-FLUOR-5-TRIFLUOROMETIL-PIRIDIN-2-IL)-PIPERAZIN-1-IL]-[5-METANOSULFONIL-2-((S)-2,2,2-TRIFLUOR-1-METIL-ETOXI)-FENIL]-METANONA, CARACTERIZADA POR LO MENOS DE 3 PICOS ELEGIDOS ENTRE LOS PICOS DE DIFRACCION DE RAYOS X OBTENIDOS CON REDIACION CuKALFA, EXPRESADOS EN 2-THETA=13,1; 14,3; 15,4; 16,2; 17,1; 17,2; 17,6; 18,0; 19,8; 20,1; 20,4; 21,0; 22,6 Y 24,3. REFERIDA TAMBIEN A LAS FORMAS CRISTALINAS B, C Y UNA FORMA AMORFA. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS CRISTALES SON UTILES EN EL TRATAMIENTO DE DOLOR, PSICOSIS, DOLOR, ESQUIZOFRENIA, DEMENCIA, ENTRE OTROS The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.