INHIBIDORES NO NUCLEOSIDOS DE TRANSCRIPTASA INVERSA

• Main Authors: YANG MINMIN, BROTHERTON-PLEISS CHRISTINE, KERTESZ DENIS JOHN
• Format: Patent
• Language: Spanish
• Published: 24.10.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

REFERIDA A UN COMPUESTO DE PIRIMIDINA DE FORMULA (I), DONDE R1 ES CO2-Tert-Bu, CO2Et, FENIL-ALQUILO C1-C3, ENTRE OTROS; R2 ES CN, -CH=CHCN, ALQUILO C1-C3, HALOGENO; R3 ES H, HALOGENO, AMINO, HALOALQUILO C1-C6; R4 ES H O AMINO; R5a Y R5b SON H, ALQUILO C1-C6, ALCOXI C1-C6, HALOGENO; R6a Y R6b SON H O JUNTOS SON ETILENO; X ES NH U O. SON COMPUESTOS PREFERIDOS: 4-[2-(1-BENCIL-PIPERIDIN-4-ILAMINO)-PIRIMIDIN-4-ILOXI]-3,5-DIMETIL-BENZONITRILO, 4-[2-(1-BENCIL-PIPERIDIN-4-ILAMINO)-5-BROMO-PIRIMIDIN-4-IL-OXI]-3,5-DIMETIL-BENZONITRILO, 4-{2-[1-(4-METANOSULFONIL-BENCIL)-PIPERIDIN-4-ILAMINO]PIRIMIDIN-4-ILOXI}-3,5-DIMETIL-BENZONITRILO, ENTRE OTROS. DICHOS COMPUESTOS INHIBEN LA TRANSCRIPTASA INVERSA DEL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH) The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5a, R5b, R6a, R6b and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.