DERIVADOS DE CROMANO, SU SINTESIS E INTERMEDIARIOS

• Main Authors: WANG YOUCHU, DAIGNEAULT SYLVAIN, CHEW WARREN, BOUCHARD LUC, WEN XIANGHUI, GUILLEMETTE VIRGINIE, SHAW CHIANG
• Format: Patent
• Language: Spanish
• Published: 18.09.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE FORMULA II, DONDE X ES 0-3; Y ES 0-5; R1 ES -R, CN, HALOGENO, -OR; R2 ES -Ph, HALOGENO, -CN, -R O -OR; R ES H, ALIFATICO C1-C6, HALOALIFATICO C1-C6. DICHO PROCEDIMIENTO CONSTA DE: a) PROPORCIONAR UN COMPUESTO DE FORMULA A Y b) REDUCIR DICHO EL COMPUESTO A PARA PROPORCIONAR EL COMPUESTO DE FORMULA I, DICHA REDUCCION SE LLEVA A CABO CON [HIDRURO DE BIS(2-METOXIETOXI)ALUMINIO Y SODIO], BH3-THF, DIBORANO, HIDRURO DE LITIO Y ALUMINIO O UNA AMINA DE BORANO. LOS COMPUESTOS MENCIONADOS SON AGONISTAS DEL SUBTIPO 2C DE LOS RECEPTORES DE SEROTONINA DEL CEREBRO Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL Methods of preparing compounds of formula I or pharmaceutically acceptable salts thereof are provided: (CH2)n R3 0T^r N. Ar R2 R4 I wherein each of R1, R2, R3, R4, x, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.