DERIVADOS DE ESTER ISOPROPILICO DEL ACIDO 4-[5-METOXI-6-(2-METIL-6-[1,2,4]TRIAZOL-1-IL-PIRIDIN-3-ILAMINO)PIRIMIDIN-4-ILOXI]-PIPERIDINA-1-CARBOXILICO Y SUS COMPOSICIONES FARMACEUTICAS

SE REFIERE AL COMPUESTO ESTER ISOPROPILICO DEL ACIDO 4-[5-METOXI-6-(2-METIL-6-[1,2,4]TRIAZOL-1-IL-PIRIDIN-3-ILAMINO)-PIRIMIDIN-4-ILOXI]-PIPERIDIN-1-CARBOXILICO. SE REFIERE TAMBIEN A UN METODO DE TRATAMIENTO Y A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES MODULADOR DEL RECEPTOR ACOPLADO A PROTEI...

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Bibliographic Details
Main Authors JONES ROBERT M, WONG AMY SIU-TING, LEHMANN JUERG
Format Patent
LanguageSpanish
Published 16.05.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:SE REFIERE AL COMPUESTO ESTER ISOPROPILICO DEL ACIDO 4-[5-METOXI-6-(2-METIL-6-[1,2,4]TRIAZOL-1-IL-PIRIDIN-3-ILAMINO)-PIRIMIDIN-4-ILOXI]-PIPERIDIN-1-CARBOXILICO. SE REFIERE TAMBIEN A UN METODO DE TRATAMIENTO Y A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES MODULADOR DEL RECEPTOR ACOPLADO A PROTEINA G RUP3 SIENDO UTIL EN EL TRATAMIENTO DE DIABETES TIPO I, RESISTENCIA A LA INSULINA, DIABETES TIPO II, HIPERLIPIDEMIA, HIPERCOLESTEROLEMIA The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[1,2,4]triazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. (Formula I)
Bibliography:Application Number: PE2007000859