DERIVADOS DE TIENOPIRIDINA Y TIENOPIRIMIDINA COMO AGENTES MODULADORES DE TIROSINQUINASA

REFERIDA A UN COMPUESTO DERIVADO DE TIENOPIRIDINA O TIENOPIRIMIDINA DE FORMULAS (I) Y (II), DONDE q ES 0,1 O 2; p ES 0 O 1; Q ES NH, N(ALQUILO), O, O UN ENLACE DIRECTO; X ES N o CH; Z ES NH, N(ALQUILO), CH2; B ES ARILO, CICLOALQUILO, HETEROARILO, ENTRE OTROS; R1 ES -(CH2)n-Ra, -CH=CH-(CH2)n-Ra, -CH=...

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Bibliographic Details
Main Authors GAUL MICHAEL DAVID, KREUTTER KEVIN DOUGLAS, BAUMANN CHRISTIAN ANDREW
Format Patent
LanguageSpanish
Published 08.03.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:REFERIDA A UN COMPUESTO DERIVADO DE TIENOPIRIDINA O TIENOPIRIMIDINA DE FORMULAS (I) Y (II), DONDE q ES 0,1 O 2; p ES 0 O 1; Q ES NH, N(ALQUILO), O, O UN ENLACE DIRECTO; X ES N o CH; Z ES NH, N(ALQUILO), CH2; B ES ARILO, CICLOALQUILO, HETEROARILO, ENTRE OTROS; R1 ES -(CH2)n-Ra, -CH=CH-(CH2)n-Ra, -CH=CH-(CH2)n-Ra, ENTRE OTROS; n ES 1, 2, 3 O 4; Ra ES H, HIDROXILO, ALQUILAMINO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ESTER 1-TIENO[2,3-d]PIRIMIDIN-4-IL-PIPERIDIN-4-ILICO DE ACIDO (4-ISOPROPIL-FENIL)-CARBAMICO; ESTER 1-TIENO[2,3-d PIRIMIDIN-4-IL-PIRROLIDIN-3-ILICO DE ACIDO (4-ISOPROPIL-FENIL)-CARBAMICO, ESTER 1-TIENO[3,2-d]PIRIMIDIN-4-IL-PIRROLIDIN-3-ILICO DE ACIDO (4-ISOPROPOXI-FENIL)-CARBAMICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DE LA PROTEINA TIROSINAQUINASA, PARTICULARMENTE SON INHIBIDORES DE LA ACTIVIDAD QUINASA DE FLT3 Y SON UTILES PARA TRATAR TRASTORNOS TALES COMO CANCERES Y OTROS DESORDENES PROLIFERATIVOS DE CELULAS The invention is directed to thienopyrimidines and thienopyridines compounds of Formula I and Formula II: where R1, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3, the use of such compounds to reduce or inhibit kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
Bibliography:Application Number: PE2006000640