COMPUESTOS DE AMINOPIRAZOL, COMPOSICIONES FARMACEUTICAS COMO INHIBIDORES DE QUINASAS

• Main Authors: REICH SIEGFRIED HEINZ, WALLACE MICHAEL B
• Format: Patent
• Language: Spanish
• Published: 02.04.2002
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE REFIERE A COMPUESTOS DE AMINOPIRAZOL DE FORMULA I DONDE R1 ES ALQUILO, HETEROARILO, CICLOALQUILO, HETEROCICLOALQUILO; R2 ES HETEROARILO, HETEROCICLOALQUILO; R3 ES H, F, Cl, Br, I, ALQUILO C1-C8; R2 Y R3 FORMAN ARILO, HETEROARILO, CICLOALQUILO, HETEROCICLOALQUILO DE 5 MIEMBROS; UN COMPUESTO PREFERIDO DE FORMULA II, LOS COMPUESTOS I SON INHIBIDORES DE LA ACTIVIDAD DE QUINASAS DEPENDIENTE DE CILINA CDK4, CDK47/COMPLEJO DE CICLINA COMO AGENTE CONTROLADOR DEL CICLO CELULAR Y PUEDE SER UTIL PARA EL TRATAMIENTO DE TUMOR, PROLIFERACION CELULAR, ANGIOGENESIS, RETINOPATIA DIABETICA, GLAUCOMA NEUROVASCULAR, ARTRITIS REUMATOIDE, PSORIASIS Amino-pyrazole compounds that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the activity cyclin-dependent kinases, thereby modulating and/or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.