DERIVADOS DE 4-ALQUIL-Y 4-ALCANOIL-PIPERIDINA SUSTITUIDOS Y SU USO COMO ANTAGONISTAS DE NEUROQUININAS

• Main Authors: JOSEPH ELISABETH LEENAERTS, FRANS EDUARD JANSSENS, FRANCOIS MARIA SOMMEN, BENOIT CHRISTIAN ALBERT GHISLAIN DE BOECK
• Format: Patent
• Language: Spanish
• Published: 08.09.2006
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

LA INVENCION SE RELACIONA CON DERIVADOS DE 4-ALQUIL- Y 4-ALCANOIL-PIPERIDINA SUSTITUIDOS QUE TIENEN ACTIVIDAD ANTAGONISTA DE NEUROQUININA, EN PARTICULAR, ACTIVIDAD ANTAGONISTA DE NK1 Y ACTIVIDAD ANATAGONISTA COMBINADA NK1/NK3 CON COMPOSICIONES QUE COMPRENDEN DICHOS DERIVADOS Y CON SU USO COMO UN MEDICAMENTO, EN ESPECIAL, PARA EL TRATAMIENTO O PROFILAXIS DE LA ESQUIZOFRENIA; EL VOMITO; ANSIEDAD Y DEPRESION; SINDROME DEL INTESTINO IRRITABLE (SII); ALTERACIONES DEL RITMO CIRCADIANO; PREECLAMSIA; NOCIRREPCION; DOLOR, EN PARTICULAR, DOLOR VISCERAL Y NEUROPATICO; PANCREATITIS; INFLAMACION NEUROGENA; ASMA; ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA (EPOC); Y TRASTORNOS DE LA MICCION, TALES COMO INCONTINENCIA URINARIA. LOS COMPUESTOS DE ACUERDO CON LA INVENCION PUEDEN REPRESENTARSE POR LA FORMULA GENERAL (I): Y COMPRENDEN TAMBIEN SUS SALES DE ADICION DE BASE O ACIDO FARAMACEUTICAMENTE ACEPTABLES; SUS FORMAS ESTEREOQUIMICAMENTE ISOMERAS; SU FORMA DE N-OXIDO; Y SUS PROFARMACOS, EN DONDE TODOS LOS SUSTITUYENTES SE DEFINEN COMO EN LA REIVINDICACION 1. The invention concerns substituted 4-alkyl- and 4-alkanoyl-piperidine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity and a combined NK1/NK3 antagonistic activity, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronic obstructive pulmonary disease (COPD) and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.