DERIVADOS DE PIRIDO [3,4-D] PIRIMIDINA COMO INHIBIDORES DE LA METALOPROTEINASA-13 DE LA MATRIZ

• Main Authors: AMY MAE BUNKER, RITA MAYURI LODAYA, MARK EUGENE MARLATT, JOSEPH ARMAND PICARD, MICHAEL LANE WALDO
• Format: Patent
• Language: Spanish
• Published: 03.03.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

ESTA INVENCION SE REFIERE A UN DERIVADO DE PIRIDO [3,4-D] PIRIMIDINA DE LA FORMULA I O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN EL QUE R1, L1, L2, V L3, Y R2 SON COMO SE HAN DEFINIDO EN LA MEMORIA DESCRIPTIVA, QUE INHIBE UNA ENZIMA METALOPROTEINASA-13 DE LA MATRIZ Y ES POR TANTO UTIL PARA TRATAR ENFERMEDADES QUE RESULTAN DEL DETERIORO DE LOS TEJIDOS MEDIADO POR LA MMP-13, TALES COMO OSTEORTRITIS, ARTRITIS REUMATOIDE, DAÑO DEL CARTILAGO, ARTRITIS PSORIASICA, ESPONDILITIS ANQUILOSANTE, INSUFICIENCIA CARDIACA, ATEROSCLEROSIS, ENFERMEDAD INFLAMATORIA DEL INTESTINO, ESCLEROSIS MULTIPLE, DEGENERACION MACULAR RELACIONADA CON LA EDAD, ENFERMEDAD PULMONAR OBSTRUTIVA CRONICA, ASMA, ENFERMEDADES PERIODONTALES, PSORIASIS, CANCER Y OSTEOPOROSIS. This invention relates to a pyrido[3,4-d]pyrimidine derivative of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, L1, L2, V, L3, and R2 are as defined in the specification, that inhibits a matrix metalloproteinase-13 enzyme and thus is useful for treating diseases resulting from MMP-13 mediated tissue breakdown such as osteoarthritis, rheumatoid arthritis, cartilage damage, psoriatic arthritis, ankylosing spondylitis, heart failure, atherosclerosis, inflammatory bowel disease, multiple sclerosis, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal diseases, psoriasis, cancer, and osteoporosis.