Non-nucleosidic inhibitors of reverse transcripta se as antagonists of cell proliferation and inducers of cell differentiation

The invention refers to the use of Reverse Transcriptase (RT) inhibitor compounds for the preparation of pharmaceutical compositions to counteract the loss of cellular differentiation in tumour and non tumour pathologies, said compound being able to bind the hydrophobic pocket on the RT subunit p66....

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Bibliographic Details
Main Authors PATRIZIA LAVIA, GUGLIELMO PALOMBINI, CLARA NERVI, RODOLFO NELLO LORENZINI, CORRADO SPADAFORA, ELISABETTA MATTEI
Format Patent
LanguageEnglish
Published 13.12.2006
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention refers to the use of Reverse Transcriptase (RT) inhibitor compounds for the preparation of pharmaceutical compositions to counteract the loss of cellular differentiation in tumour and non tumour pathologies, said compound being able to bind the hydrophobic pocket on the RT subunit p66. Particularly preferred for such uses are the following compounds: nevirapine, efavirenz, delavirdine, corresponding salts and/or pharmaceutically acceptable derivatives thereof.
Bibliography:Application Number: OA20041000180