Genetically modified t cell receptor mice

Disclosed is a genetically modified non-human animal, comprising in its genome: -an unrearranged T cell receptor (TCR) α variable gene locus comprising at least one human Vα segment and at least one human Jα segment, wherein the TCRα variable gene locus is operably linked to a non-human TCRα constan...

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Bibliographic Details
Main Authors Murphy, Andrew, Mcwhirter, John, Voronina, Vera, Macdonald, Lynn, Tu, Naxin, Stevens, Sean, Meagher, Karolina, Gurer, Cagan
Format Patent
LanguageEnglish
Published 31.05.2024
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
NEW BREEDS OF ANIMALS
ORGANIC CHEMISTRY
PEPTIDES
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
TRAPPING
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Summary:Disclosed is a genetically modified non-human animal, comprising in its genome: -an unrearranged T cell receptor (TCR) α variable gene locus comprising at least one human Vα segment and at least one human Jα segment, wherein the TCRα variable gene locus is operably linked to a non-human TCRα constant gene sequence, wherein the unrearranged TCRα variable gene locus replaces an endogenous non-human TCRα variable gene locus, and/or -an unrearranged TCRβ variable gene locus comprising at least one human Vβ segment, at least one human Dβ segment, and at least one human Jβ segment, wherein the unrearranged TCRβ variable gene locus is operably linked to a non-human TCRβ constant gene sequence, wherein the unrearranged TCRβ variable gene locus replaces an endogenous non-human TCRβ variable gene locus.
Bibliography:Application Number: NZ20120796690