Conjugation linkers containing 2,3-diaminosuccinyl group

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the...

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Main Authors Yang, Qingliang, Xie, Hongsheng, Tong, Yanhong, Ye, Zhicang, Chen, Binbin, Zhao, Linyao, Zhao, Robert Yongxin, Chao, Mingjun, Tong, Qianqian, Zhou, Xiaomai, Guo, Huihui, Yang, Chengyu, Xu, Yifang, Zhuo, Xiaotao, Huang, Yuanyuan, Gai, Shun, Zheng, Jun, Li, Wenjun, Bai, Lu, Lei, Jun, Jia, Junxiang, Lin, Chen, Ye, Hangbo, Yang, Yanlei, Guo, Zhixiang
Format Patent
LanguageEnglish
Published 24.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.
Bibliography:Application Number: NZ20180775656