Uti fusion proteins
The present invention provides UTI fusion proteins, DNA sequences for producing the same, and pharmaceutical compositions and methods of using the same. In a specific embodiment the UTI fusion protein comprises amino acids 1-149 of SEQ ID NO:1, which consists of the mature human UTI protein (amino a...
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
31.03.2023
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides UTI fusion proteins, DNA sequences for producing the same, and pharmaceutical compositions and methods of using the same. In a specific embodiment the UTI fusion protein comprises amino acids 1-149 of SEQ ID NO:1, which consists of the mature human UTI protein (amino acids residues 1-143) connected via a GS linker (amino acids 144-149) that is linked directly to a Fc portion comprising the hinge, second (CH2) and third (CH3) constant regions of the wild-type human IgG1 protein. These fusion proteins have an increased thermostability. |
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Bibliography: | Application Number: NZ20150760008 |