Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

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Bibliographic Details
Main Authors Yang, Qingliang, Xie, Hongsheng, Huang, Yuanyuan, Gai, Shun, Li, Chen, Zhao, Yongxin Robert, Zhao, Linyao, Li, Wenjun, Bai, Lu, Gao, Shuihong, Jia, Junxiang, Ye, Hangbo, Tong, Qianqian, Yang, Yanlei, Zhou, Xiaomai, Zhu, Haifeng, Cao, Minjun, Guo, Zhixiang, Ye, Zhichang, Guo, Huihui, Yang, Chengyu, Xu, Yifang, Wang, Chunyan
Format Patent
LanguageEnglish
Published 30.07.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
Bibliography:Application Number: NZ20160752394