Oxaborole esters and uses thereof

Trypanosomatids are a group of kinetoplastid protozoa distinguished by having only a single flagellum. Trypanosomatids are responsible for diseases such as South American trypanosomiasis (Chagas Disease) and African Animal Trypanosomosis (AAT). The present invention provides oxaborole ester compound...

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Bibliographic Details
Main Authors Zhang, Yong-Kang, Jacobs, Robert T, Carter, David Scott, Witty, Michael John, Akama, Tsutomu, Liu, Yang, Plattner, Jacob J, Halladay, Jason S
Format Patent
LanguageEnglish
Published 26.06.2020
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Trypanosomatids are a group of kinetoplastid protozoa distinguished by having only a single flagellum. Trypanosomatids are responsible for diseases such as South American trypanosomiasis (Chagas Disease) and African Animal Trypanosomosis (AAT). The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with trypanosomatids, such as Chagas Disease and AAT. The present invention therefore provides a compound of formula I or a pharmaceutically acceptable salt thereof, wherein each of R1, R1a, R2, R3, R4, R5, R6, and L is as defined and described in the specification.
Bibliography:Application Number: NZ20170746906