Pentaaza macrocyclic ring complexes possessing oral bioavailability

Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal coordinated by a macrocycle comprising the pentaaza 15-membered macrocyclic ring corresponding to Formula A and two axial ligands having the formula...

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Bibliographic Details
Main Authors Riley, Dennis P, Keene, Jeffery L, Schall, Otto F
Format Patent
LanguageEnglish
Published 05.07.2024
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal coordinated by a macrocycle comprising the pentaaza 15-membered macrocyclic ring corresponding to Formula A and two axial ligands having the formula -OC(O)X1. (Formula A) each of the two axial ligands has the formula -OC(=O)X1wherein each X1is independently substituted or unsubstituted phenyl or -C(-X2)(-X3)(-X4); each X2is independently substituted or unsubstituted phenyl, or substituted or unsubstituted alkyl; each X3is independently hydrogen, hydroxyl, alkyl, amino, -X5C(=O)R13where X5 is NH or O, and R13is C1-C18alkyl, substituted or unsubstituted aryl or C1-C18aralkyl, or -OR14, where R14is C1-C18alkyl, substituted or unsubstituted aryl or C1-C18aralkyl, or together with X4is (=O); and each X4is independenly hydrogen or together with X3is (=O).
Bibliography:Application Number: NZ20160740359