New hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them

Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, A and n are as defined in the description as B-cell lymphoma 2 (Bcl-2) inhibitors, pharmaceutical compositions thereof, and their use as pro-apoptotic agents and in the treatment of cancers.

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Bibliographic Details
Main Authors Geneste, Olivier, Paczal, Attila, Proszenyák, Ágnes, Davidson, James Edward Paul, Kotschy, András, Sipos, Szabolcs, Murray, James Brooke, Chanrion, Maïa, Bálint, Balázs, Szlávik, Zoltán
Format Patent
LanguageEnglish
Published 30.08.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, A and n are as defined in the description as B-cell lymphoma 2 (Bcl-2) inhibitors, pharmaceutical compositions thereof, and their use as pro-apoptotic agents and in the treatment of cancers.
Bibliography:Application Number: NZ20160738469