Synthesis of polycyclic-carbamoylpyridone compounds

A synthetic method for preparing polycyclic-carbamoylpyridone compounds of Formula I where the bridged ring system is formed prior to a final hydroxyl deprotection step. A synthesis of Bictegravir is exemplified.

Saved in:
Bibliographic Details
Main Authors Trinidad, Jonathan, Ikemoto, Norihiro, Griggs, Nolan, Keaton, Katie, Enquist, John, Schrier, Kate, Chiu, Anna, Peng, Zhihui, Herpt, Jochem, Hale, Christopher, Leeman, Michel, Kraft, Matt, Lazerwith, Scott, Waltman, Andrew
Format Patent
LanguageEnglish
Published 25.08.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:A synthetic method for preparing polycyclic-carbamoylpyridone compounds of Formula I where the bridged ring system is formed prior to a final hydroxyl deprotection step. A synthesis of Bictegravir is exemplified.
Bibliography:Application Number: NZ20150736697