(2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase i inhibitors

This disclosure relates to tert-butyl (2S)-2-[[(1S)-2-amino-2-oxo-1-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]ethyl]carbamoyl]-1,4-oxazepane-4-carboxylate. This compound is an intermediate in the synthesis of compounds of formula (I). The compounds of formula (I) are dipeptidyl...

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Main Authors Swallow, Steven, Lönn, Hans, Doyle, Kevin, Jones, Graham, Palmer, Nicholas, Macritchie, Jaqueline, Watson, David, Aurell, Carl-Johan, Van De Poël, Amanda, Pontén, John Fritiof, Karlsson, Staffan Po, Connolly, Stephen
Format Patent
LanguageEnglish
Published 30.09.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This disclosure relates to tert-butyl (2S)-2-[[(1S)-2-amino-2-oxo-1-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]ethyl]carbamoyl]-1,4-oxazepane-4-carboxylate. This compound is an intermediate in the synthesis of compounds of formula (I). The compounds of formula (I) are dipeptidyl peptidase inhibitors useful in the treatment of respiratory disorders.
Bibliography:Application Number: NZ20150734768