Compositions comprising e. coli o25b antigen, uses thereof and methods of manufacture

• Main Authors: Kowarik Michael T, Kemmler Stefan J, Häuptle Micha A, Mally Manuela, Wetter Michael L, Gambillara Veronica
• Format: Patent
• Language: English
• Published: 26.01.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells comprising enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce 025B bioconjugates, wherein said bioconjugates comprise O25B linked to a carrier...