Compositions comprising e. coli o25b antigen, uses thereof and methods of manufacture
Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells comprising enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce 025B bioconjugates, wherein said bioconjugates comprise O25B linked to a carrier...
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Main Authors | , , , , , |
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Format | Patent |
Language | English |
Published |
26.01.2018
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Subjects | |
Online Access | Get full text |
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Summary: | Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells comprising enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce 025B bioconjugates, wherein said bioconjugates comprise O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, comprising O25B and/or bioconjugates comprising O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further comprise one or more additional bioconjugates. |
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Bibliography: | Application Number: NZ20150723328 |