Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crystalline forms thereof

The present invention provides processes for the manufacture of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene (formula I) and crystalline forms thereof. Also disclosed are compounds useful as intermediates in the methods of the invention...

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Bibliographic Details
Main Authors Bartels, Bjoern, Ran, Frederic, Trussardi, René, Diodone, Ralph, Pfleger, Christophe, Grassmann, Olaf, Rothenhaeusler, Benno, Hartung, Thomas, Schwitter, Urs, Hoffmann-Emery, Fabienne, Adam, Jean-Michel
Format Patent
LanguageEnglish
Published 27.03.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides processes for the manufacture of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene (formula I) and crystalline forms thereof. Also disclosed are compounds useful as intermediates in the methods of the invention.
Bibliography:Application Number: NZ20140720340