Methods of treating or preventing cholesterol related disorders

• Main Authors: Gibbs, John P, Wasserman, Scott, Scott, Robert Andrew Donald, Chan, Joyce Chi Yee, Stein, Evan, Clogston, Christi L, Osslund, Timothy David, Dias, Clapton S
• Format: Patent
• Language: English
• Published: 27.08.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed and claimed is a method of lowering serum LDL cholesterol in a patient comprising administering at least one anti-PCSK9 antibody to the patient in need thereof at a dose of about 105-280mg wherein said dose is to be administered at a frequency of from once per week to once every four weeks, and wherein said medicament is capable of lowering said serum LDL cholesterol level by at least about 15%. Wherein PCSK9 comprises the amino acids of SEQ ID NO 1 and the antibody is defined by 90% identity to SEQ Id NO: 23 and 49 or by the CDRs therein.