Methods of treating or preventing cholesterol related disorders

Disclosed and claimed is a method of lowering serum LDL cholesterol in a patient comprising administering at least one anti-PCSK9 antibody to the patient in need thereof at a dose of about 105-280mg wherein said dose is to be administered at a frequency of from once per week to once every four weeks...

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Bibliographic Details
Main Authors Gibbs, John P, Wasserman, Scott, Scott, Robert Andrew Donald, Chan, Joyce Chi Yee, Stein, Evan, Clogston, Christi L, Osslund, Timothy David, Dias, Clapton S
Format Patent
LanguageEnglish
Published 27.08.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed and claimed is a method of lowering serum LDL cholesterol in a patient comprising administering at least one anti-PCSK9 antibody to the patient in need thereof at a dose of about 105-280mg wherein said dose is to be administered at a frequency of from once per week to once every four weeks, and wherein said medicament is capable of lowering said serum LDL cholesterol level by at least about 15%. Wherein PCSK9 comprises the amino acids of SEQ ID NO 1 and the antibody is defined by 90% identity to SEQ Id NO: 23 and 49 or by the CDRs therein.
Bibliography:Application Number: NZ20120717550