Pyrazole derivatives as jak inhibitors

Disclosed herein is a pyrazole derivative compound of general formula (I), wherein the subsittuents are defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as JAK inhibitors, as such is useful in the tr...

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Main Authors GIULIO MATASSA VICTOR, PAGES SANTACANA LLUIS MIQUEL, TALTAVULL MOLL JOAN, EASTWOOD PAUL ROBERT, GONZALEZ RODRIGUES JACOB, BACH TANA JORDI
Format Patent
LanguageEnglish
Published 29.05.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein is a pyrazole derivative compound of general formula (I), wherein the subsittuents are defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as JAK inhibitors, as such is useful in the treatment of a pathological condition or disease selected from myeloproliferative disorders, leukemia, lymphoid malignancies and solid tumors; bone marrow and organ transplant rejection; and immune-mediated diseases, or wherein the pathological condition or disease is selected from inflammatory diseases. Compounds of the invention include: (S)-N-(1-phenylethyl)-2-(pyrazolo[1,5-a]pyrazin-3-yl)pyrimidin-4-amine, 3-{ (3R)-3-[Methyl(2-pyrazolo[1,5-a]pyrazin-3-ylpyrimidin-4-yl)amino]piperidin-1-yl} -3-oxopropanenitrile and 2-(Pyrazolo[1,5-a]pyrazin-3-yl)-N4-(tetrahydro-2H-pyran-4-yl)pyrimidine-4,5-diamine
Bibliography:Application Number: NZ20110701440