Processes and intermediates for the preparation of a pde10 inhibitor

Disclosed herein is a process for the preparation of compounds of Formula (II), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thi...

Full description

Saved in:
Bibliographic Details
Main Authors LITTLE THOMAS L, MCDERMOTT MICHAEL JAMES, CUTSHALL NEIL S, LUKE WAYNE DOUGLAS, REINEKE KARL E, BROT ELISABETH C A, JONAS MARCO, GAGE JENNIFER LYNN
Format Patent
LanguageEnglish
Published 31.03.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:Disclosed herein is a process for the preparation of compounds of Formula (II), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, which is useful in the inhibition of PDE10.
Bibliography:Application Number: NZ20140630810