Compounds useful as inhibitors of atr kinase

Disclosed are 2-amino-6-fluoro-N-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives and analogues such as 2-amino-6-fluoro-N-(5-fluoro-4-(4-(4-(oxetan-3-yl)piperazine-1-carbonyl)piperidin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (I-G-32). Also disclosed is a pharmaceu...

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Bibliographic Details
Main Authors Davis Rebecca, Twin Heather, Pierard Francoise, Fraysse Damien, Davis Chris, Boyall Dean, Durrant Steven, Etxebarria I Jardi Gorka, Middleton Donald, Jimenez Juan-Miguel, Charrier Jean-Damien, Studley John, Pinder Joanne, Ahmad Nadia, Shaw David, Knegtel Ronald, Panesar Maninder, Odonnell Michael, Kay David, Storck Pierre-Henri
Format Patent
LanguageEnglish
Published 26.05.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are 2-amino-6-fluoro-N-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives and analogues such as 2-amino-6-fluoro-N-(5-fluoro-4-(4-(4-(oxetan-3-yl)piperazine-1-carbonyl)piperidin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (I-G-32). Also disclosed is a pharmaceutical composition comprising the compound I-G-32 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, for use in the treatment of cancer. Also disclosed is the synthetic intermediate tert-butyl N-(3-fluoro-5-aminopyridin-4-yl)-piperidine-4-carboxylate and its use in the preparation of (I-G-32).
Bibliography:Application Number: NZ20130630457