Amidine substituted beta - lactam compounds, their preparation and use as antibacterial agents

• Main Authors: BROETZ-OESTERHELT HEIKE, REDDY ANDHE, LIANG HONG, TAJAMMUL SABIHA, YANG ZHIXIANG, MAITI SAMARENDRA N, GAO CHUANJUN, KHAN JEHANGIR, JIA GUOFENG, WIEGAND IRITH, BISWAJEET GANGULI, HENA MOSTAFA, MOHAMMAD RAHIM, SCHIFFER GUIDO, KLENKE BURKHARD, YIP JUDY, LIGONG OU
• Format: Patent
• Language: English
• Published: 31.03.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to novel -lactam compounds of formula (I), their preparation and use. In particular, this disclosure relates to novel -lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation. The compounds are useful in treating bacterial infections. Examples of compounds that fall within the scope of formula (I) are: (2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-{ [2-(4-carbamimidoyl-3-hydroxyphenoxy)ethoxy]imino} -N-[(3S)-2,2-dimethyl-4-oxo-1-(sulfooxy)azetidin-3-yl]ethanamide; (2S,3S)-3-{ [(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-{ [2-(4-carbamimidoyl-3-hydroxyphenoxy)-ethoxy]imino} acetyl]amino} -2-methyl-4-oxoazetidine-1-sulfonic acid and (2S,3S)-3-{ [(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-({ 2-[(6-carbamimidoylpyridin-3-yl)oxy]ethoxy} -imino)acetyl]amino} -2-methyl-4-oxoazetidine-1-sulfonic acid