Trpv4 antagonists

The present disclosure relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The disclosure further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to...

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Bibliographic Details
Main Authors GOODMAN KRISTA B, BROOKS CARL, STOY PATRICK, HOANG TRAM H, CHEUNG MUI, HILFIKER MARK A, YE GUOSEN, HAMMOND MARLYS, PATTERSON JACLYN R, EIDAM HILARY SCHENCK
Format Patent
LanguageEnglish
Published 27.02.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The disclosure further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
Bibliography:Application Number: NZ20120618221