Piperidinone carboxamide azaindane cgrp receptor antagonists

Disclosed are spiro condensed piperidinone azaindane pyrrolo pyridine carboxamide derivatives of formula I which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. An example of such a compound is (6S)-N-[(3S,5S,6R...

Full description

Saved in:
Bibliographic Details
Main Authors BELL IAN M, FRALEY MARK E, MITCHELL HELEN J, GINNETTI ANTHONY, WANG CHENG, PAONE DANIEL V, STAAS DONNETTE D, STEVENSON HEATHER E, GALLICCHIO STEVEN N, ZARTMAN C. BLAIR
Format Patent
LanguageEnglish
Published 26.06.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Disclosed are spiro condensed piperidinone azaindane pyrrolo pyridine carboxamide derivatives of formula I which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. An example of such a compound is (6S)-N-[(3S,5S,6R)-6-Methyl-5-(2-methylphenyl)-2-oxo-1-(2,2,2-trifluoroethyI)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo [2,3-b]pyridine]-3-carboxamide. Also disclosed is the use of said compounds in the manufacture of a medicament for the prevention or treatment of diseases in which CGRP is involved, for example migraines.
Bibliography:Application Number: NZ20110610468