Conjugates for the prevention or treatment of nicotine addiction
Disclosed is a hapten-carrier conjugate of formula III. The conjugate includes compounds such as trans-4-amino-N-(3-{ 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl} propyl)cyclohexanecarboxamide and 4-mercapto-N-[2-({ 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl} oxy)ethyl]butanamide which are conjug...
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Main Authors | , , , , , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
28.11.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Disclosed is a hapten-carrier conjugate of formula III. The conjugate includes compounds such as trans-4-amino-N-(3-{ 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl} propyl)cyclohexanecarboxamide and 4-mercapto-N-[2-({ 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl} oxy)ethyl]butanamide which are conjugated to an optionally modified carrier protein selected from bacterial toxoids, immunogenic substances, viruses, virus-like particles, protein complexes, proteins, polypeptides, liposomes and immuno-stimulating complexes. The conjugates are useful for aiding smoking cessation in smokers. |
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Bibliography: | Application Number: NZ20110603819 |