Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. In one embodiment the compound is N-(4-{ [4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohe...

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Main Authors TAO ZHI-FU, WANG GARY T, HANSEN TODD M, HASVOLD LISA, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, MANTEI ROBERT, BRUNCKO MILAN, SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, WENDT MICHAEL, ELMORE STEVEN, DING HONG, HEXAMER LAURA, KUNZER AARON R
Format Patent
LanguageEnglish
Published 28.11.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. In one embodiment the compound is N-(4-{ [4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl} -2-nitrophenyl)-4-cyanopiperidine-1-carboxamide.
Bibliography:Application Number: NZ20100603463