Heteroaryl compounds and uses thereof

Disclosed herein are pyrimidine substituted compounds of general formula I-b, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as inhibitors of protein kinase, particularly BTK, JAK3 and TEC-kinase and as such are useful in the treat...

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Main Authors PETTER RUSSELL, WESTLIN III WILLIAM FREDERICK, MAZDIYASNI HORMOZ, SINGH JUSWINDER, NIU DEQIANG, QIAO LIXIN, TESTER RICHLAND WAYNE, KLUGE ARTHUR F
Format Patent
LanguageEnglish
Published 31.10.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are pyrimidine substituted compounds of general formula I-b, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as inhibitors of protein kinase, particularly BTK, JAK3 and TEC-kinase and as such are useful in the treatment of autoimmune disease, heretoimmune disease, inflammatory disease, cancer, disease of the bone and joints, a thromboembolic disorder, a neurodegenerative disorder, or a solid or hematologic malignancy.
Bibliography:Application Number: NZ20100600631