Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
Provided herein are compounds that selectively modulate the sphingosine 1 phosphate receptor including compounds which modulate subtype 1 of the SlP receptor, specifically, compounds of formula I-R and I-S wherein the variables are defined in the specification.. Methods of chiral synthesis of such c...
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Main Authors | , , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
25.07.2014
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Subjects | |
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Abstract | Provided herein are compounds that selectively modulate the sphingosine 1 phosphate receptor including compounds which modulate subtype 1 of the SlP receptor, specifically, compounds of formula I-R and I-S wherein the variables are defined in the specification.. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated. In one embodiment the compounds if (R)-3-(3-(1-amino-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile. |
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AbstractList | Provided herein are compounds that selectively modulate the sphingosine 1 phosphate receptor including compounds which modulate subtype 1 of the SlP receptor, specifically, compounds of formula I-R and I-S wherein the variables are defined in the specification.. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated. In one embodiment the compounds if (R)-3-(3-(1-amino-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile. |
Author | TAMIYA JUNKO BROOKS JENNIFER L BRAHMACHARY ENUGURTHI SCOTT FIONA LORRAINE TIMONY GREGG ALAN BOEHM MARCUS F YEAGER ADAM RICHARD MOORJANI MANISHA PEACH ROBERT HANSON MICHAEL ALLEN HUANG LIMING MARTINBOROUGH ESTHER |
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Snippet | Provided herein are compounds that selectively modulate the sphingosine 1 phosphate receptor including compounds which modulate subtype 1 of the SlP receptor,... |
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SubjectTerms | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING |
Title | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis |
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