Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis

Provided herein are compounds that selectively modulate the sphingosine 1 phosphate receptor including compounds which modulate subtype 1 of the SlP receptor, specifically, compounds of formula I-R and I-S wherein the variables are defined in the specification.. Methods of chiral synthesis of such c...

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Main Authors TAMIYA JUNKO, BROOKS JENNIFER L, YEAGER ADAM RICHARD, MOORJANI MANISHA, MARTINBOROUGH ESTHER, PEACH ROBERT, HUANG LIMING, SCOTT FIONA LORRAINE, BRAHMACHARY ENUGURTHI, BOEHM MARCUS F, TIMONY GREGG ALAN, HANSON MICHAEL ALLEN
Format Patent
LanguageEnglish
Published 25.07.2014
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:Provided herein are compounds that selectively modulate the sphingosine 1 phosphate receptor including compounds which modulate subtype 1 of the SlP receptor, specifically, compounds of formula I-R and I-S wherein the variables are defined in the specification.. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated. In one embodiment the compounds if (R)-3-(3-(1-amino-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile.
Bibliography:Application Number: NZ20100599915