Thiophene analogues for the treatment or prevention of Flavivirus infections

• Main Authors: KUMAR DAS, SANJOY, YANNOPOULOS, CONSTANTIN G, CHAN CHUN KONG, LAVAL, POISSON, CARL
• Format: Patent
• Language: English
• Published: 28.03.2013
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

596922 Thiophene analogues for the treatment or prevention of Flavivirus infections Disclosed are compounds of Formula (IA) or a pharmaceutically acceptable salt thereof. A composition comprising these compounds, pegylated interferon-alpha and ribavirin is also disclosed. Use of the composition for treating hepatitis C viral infection and intermediates for the synthesis of compounds of formula (IA) is also disclosed. The disclosed compounds include: 5-(3,3-DIMETHYL-BUT-1-YNYL)-3-[(TRANS-4-MEIHOXY-CYCLOHEXYL)- (TRANS-4-METHYLCYCLOHEXANECARBONYL)-AMINO]-THIOPHENE-2-CARBOXYLIC ACID; 5-(3, 3-DIMETHYL-BUT-1-YNYL)-3-[(TRANS-4-METHYL-CYCLOHEXANECARBONYL)-(CIS-4- [1 ,2,4]TRIAZOL-1-YL-CYCLOHEXYL)-AMINO]-THIOPHENE-2-CARBOXYLIC ACID and 5-(3,3-DIMETHYL-BUT-1-YNYL)- 3-[(TRANS-4-METHYL -CYCLOHEXANECARBONYL)-(TRANS-4-[1 ,2,4]TRIAZOL-1-YL-CYCLOHEXYL)-AMINO]-THIOPHENE-2-CARBOXYLIC ACID